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Morphology of this secondary clone strictly depends on the type of second genetic hit: inactivation of the BAP1 ( BRCA1 -associated protein) gene is the hallmark of BAP1 -inactivated nevus (BIN) (33, 34)

The occurrence of oral mucosal melanoma is the primary reason why all focally pigmented lesions and most diffusely pigmented lesions require a biopsy for diagnosis